BIO-TRAC
FAES/NIH
Building 60
Room 237
1 Cloister Court
Bethesda, MD
20814-1460
301-496-8290
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TRAC 31: Vaccines: Development and Evaluation of Efficacy
Vaccines are used or developed for a wide range of diseases such as cancer, auto-immune diseases, allergies, and for the prevention of communicable and parasitic diseases. The purpose of this course is to provide an overview of a broad spectrum of vaccine related topics and their mode of action making it valuable for any scientist working with or on vaccines regardless of the participant’s scientific background.
Topics: Overview of the immune system and the induction of an immune response highlighting crucial factors for vaccinology; protein and peptide vaccines, viral vaccines (pox- and avi-viruses, adenoviruses), bacterial vaccines; Cutting-edge vaccines such as DNA vaccines, pulsed dendritic cells, nanoparticles; Purpose of adjuvants, classes of adjuvants with in depth discussion of adjuvants used in the clinic, molecular (‘designer”) adjuvants; Immunization strategies (regimen, route of immunization); Monitoring the immune response and evaluation of vaccine efficacy (in vitro assays such as ELISA, immunofluorescence assays, ELISPOT; Flow cytometry - will be discussed in context with intracellular staining, tetramer staining and phenotyping of vaccine-reactive cells). Laboratory: injection routes, gene gun immunization, preparing vaccine emulsions, evaluating immune sera by ELISA and Western Blot.
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| THREE DAY COURSE |
| TRAC 31-FL |
| Sept. 8-10, 2010 |
| REGISTER-FL |
| TRAC 31-WN |
| Feb. 9-11, 2011 |
| REGISTER-WN |
| TIME |
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9:00 - 5:00 pm
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| 21 Contact Hours |
| FEE |
| $750 |
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